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FORMULATION AND EVALUATION OF AMLODIPINE BESYLATE TABLETS IBD

LAP LAMBERT ACADEMIC PUBLISHIN
07 / 2012
9783659190445
Inglés

Sinopsis

Amlodipine used as an anti-hypertensive and in the treatment of angina. FDT of amlodipine besylate were prepared using different superdisintegrants by direct compression method. Mannitol was used as a diluent. Aspartame and Acesulfame Potassium were used for unpleasant taste masked from the amlodipine by cosifting and serial of blending with other excipients. The mixed final blend was then compressed into tablets. The formulations were evaluated for weight variation, hardness, friability, wetting time, disintegrating time, dissolution, taste evaluation study and in vitro dispersion time.

PVP
72,88